Procleave: Predicting Protease-specific Substrate Cleavage Sites by Combining Sequence and Structural Information.

ABSTRACT: Proteases are enzymes that cleave and hydrolyse the peptide bonds between two specific amino acid residues of target substrate proteins. Protease-controlled proteolysis plays a key role in the degradation and recycling of proteins, which is essential for various physiological processes. Thus, solving the substrate identification problem will have important implications for the precise understanding of functions and physiological roles of proteases, as well as for therapeutic target identification and pharmaceutical applicability. Consequently, there is a great demand for bioinformatics methods that can predict novel substrate cleavage events with high accuracy by utilizing both sequence and structural information. In this study, we present Procleave, a novel bioinformatics approach for pre

SUBMITTER: Li F 

PROVIDER: S-EPMC7393547 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature