Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC7393575 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Genomics, proteomics & bioinformatics 20200201 1
BRAF is a serine/threonine kinase that harbors activating mutations in ∼7% of human malignancies and ∼60% of melanomas. Despite initial clinical responses to BRAF inhibitors, patients frequently develop drug resistance. To identify candidate therapeutic targets for BRAF inhibitor resistant melanoma, we conduct CRISPR screens in melanoma cells harboring an activating BRAF mutation that had also acquired resistance to BRAF inhibitors. To investigate the mechanisms and pathways enabling resistance ...[more]