Non-animal methods to predict skin sensitization (II): an assessment of defined approaches ^*.

ABSTRACT: Skin sensitization is a toxicity endpoint of widespread concern, for which the mechanistic understanding and concurrent necessity for non-animal testing approaches have evolved to a critical juncture, with many available options for predicting sensitization without using animals. Cosmetics Europe and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods collaborated to analyze the performance of multiple non-animal data integration approaches for the skin sensitization safety assessment of cosmetics ingredients. The Cosmetics Europe Skin Tolerance Task Force (STTF) collected and generated data on 128 substances in multiple in vitro and in chemico skin sensitization assays selected based on a systematic assessment by the STTF. These assay

SUBMITTER: Kleinstreuer NC 

PROVIDER: S-EPMC7393691 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature