Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study.

ABSTRACT:

Background

Studies have shown that abnormal changes of specific-gene DNA methylation in leukocytes may be associated with an elevated risk of cancer. However, associations between the methylation of the zinc-related genes, WT1 and CA10, and breast cancer risk remain unknown.

Methods

The methylation of WT1 and CA10 was analyzed by methylation-sensitive high-resolution-melting (MS-HRM) in a case-control study with female subjects (N = 959). Logistic regression was used to analyze the associations, and propensity score (PS) method was used to adjust confounders.

Results

The results showed that WT1 hypermethylation was associated with an increased risk of breast cancer, with an odds ratio (OR) of 3.07 [95% confidence interval (CI): 1.67-5.64, P < 0.01]. Subgroup analyses

SUBMITTER: Ge A 

PROVIDER: S-EPMC7393705 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature