Association studies of dopamine synthesis and metabolism genes with multiple phenotypes of heroin dependence.

ABSTRACT:

Background

Heroin dependence is a complex disease with multiple phenotypes. Classification of heroin users into more homogeneous subgroups on the basis of these phenotypes could help to identify the involved genetic factors and precise treatments. This study aimed to identify the association between genetic polymorphisms of DA synthesis and metabolism genes, including tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), solute carrier family 6 member 3 (SLC6A3) and DA beta-hydroxylase (DBH), with six important phenotypes of heroin dependence.

Methods

A total of 801 heroin dependent patients were recruited and fourteen potential functional single nucleotide polymorphisms (SNPs) were genotyped by SNaPshot. Associations between SNPs with six phenotypes were mainly assessed by b

SUBMITTER: Li Y 

PROVIDER: S-EPMC7393710 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature