CD4⁺ T Cell Interstitial Migration Controlled by Fibronectin in the Inflamed Skin.

ABSTRACT: The extracellular matrix (ECM) is extensively remodeled during inflammation providing essential guidance cues for immune cell migration and signals for cell activation and survival. There is increasing interest in the therapeutic targeting of ECM to mitigate chronic inflammatory diseases and enhance access to the tumor microenvironment. T cells utilize the ECM as a scaffold for interstitial migration, dependent on T cell expression of matrix-binding integrins α_Vβ₁/α_Vβ₃ and tissue display of the respective RGD-containing ligands. The specific ECM components that control T cell migration are unclear. Fibronectin (FN), a canonical RGD-containing matrix component, is heavily upregulated in inflamed tissues and in vitro can serve as a substrate

SUBMITTER: Fernandes NRJ 

PROVIDER: S-EPMC7393769 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature