Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets.

ABSTRACT: Natural killer (NK) cells recognize and eliminate infected and malignant cells. Their life histories are poorly understood, particularly in humans, due to lack of informative models and endogenous clonal markers. Here, we apply transplantation of barcoded rhesus macaque hematopoietic cells to interrogate the landscape of NK cell production, expansion, and life histories at a clonal level long term and after proliferative challenge. We identify oligoclonal populations of rhesus CD56^-CD16⁺ NK cells that are characterized by marked expansions and contractions over time yet remained long-term clonally uncoupled from other hematopoietic lineages, including CD56⁺CD16^- NK cells. Individual or groups of CD56^-CD16⁺ expanded clones se

SUBMITTER: Wu C 

PROVIDER: S-EPMC7393805 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature