Systematic review with meta-analysis: association between Helicobacter pylori CagA seropositivity and odds of inflammatory bowel disease.

ABSTRACT:

Background

Accumulating data support a protective role of Helicobacter pylori against inflammatory bowel diseases (IBD), which might be mediated by strain-specific constituents, specifically cagA expression.

Aim

To perform a systematic review and meta-analysis to more clearly define the association between CagA seropositivity and IBD.

Methods

We identified comparative studies that included sufficient detail to determine the odds or risk of IBD, Crohn's disease (CD) or ulcerative colitis (UC) amongst individuals with vs without evidence of cagA expression (eg CagA seropositivity). Estimates were pooled using a random effects model.

Results

Three clinical studies met inclusion criteria. cagA expression was represented by CagA seropositivity in all studies. Compar

SUBMITTER: Tepler A 

PROVIDER: S-EPMC7393806 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature