Genome-wide DNA methylation profiling identifies epigenetic signatures of gastric cardiac intestinal metaplasia.

ABSTRACT:

Background

Measuring the DNA methylome may offer the opportunity to identify novel disease biomarkers and insights into disease mechanisms. Although aberrant DNA methylation has been investigated in many human cancers and precancerous lesions, the DNA methylation landscape of gastric cardiac intestinal metaplasia (IM) remains unknown. Therefore, we aimed to investigate the genome-wide DNA methylation landscape and to search for potential epigenetic biomarkers of gastric cardiac IM.

Methods

Histopathologic profiling was performed on a total of 118 gastric cardiac biopsies from cancer-free individuals. Genome-wide DNA methylation analysis was performed on 11 gastric cardiac mucosal biopsies (IM = 7; normal = 4) using Illumina 850K microarrays. Transcriptional relevance of any

SUBMITTER: Lin R 

PROVIDER: S-EPMC7393819 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature