Gut microbiota-associated metabolite trimethylamine N-Oxide and the risk of stroke: a systematic review and dose-response meta-analysis.

ABSTRACT:

Aims

Several epidemiological studies have examined the association between trimethylamine N-Oxide (TMAO) and stroke risk; however, the results are still inconclusive. The purpose of this meta-analysis was to evaluate the relationship between TMAO concentrations and stroke risk.

Methods

PubMed, Scopus, Cochrane and ProQuest search engines were systematically searched up to 18 June 2019. All of the studies that evaluated the relationship between TMAO and stroke were included in the systematic review and eligible studies were included into the meta-analysis. Meta-regression and subgroup analysis were also employed to find the source of heterogeneity.

Results

Eight studies (two cross-sectional studies, two cohort studies, three case-control studies and one nested case-con

SUBMITTER: Farhangi MA 

PROVIDER: S-EPMC7393891 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature