Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis.

ABSTRACT: Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric means (GM = 19.14 μg ml^-1)). However, compounds 2 (GM = 50 μg ml^-1) and 3 (GM = 47.19 μg ml^-1) have presented only anti-Candida action. Compounds 3 and 5 did not present cytotoxic action. Compound 5 did not produce dermal and mucosal toxicity. In addition, this comp

SUBMITTER: da Rosa Monte Machado G 

PROVIDER: S-EPMC7394049 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature