Proteomic analysis of human cervical adenocarcinoma mucus to identify potential protein biomarkers.

ABSTRACT:

Background

Cervical cancer is the most common gynecological cancer, encompassing cervical squamous cell carcinoma, adenocarcinoma, and other epithelial tumors. There are many diagnostic methods to detect cervical cancers but no precision screening tool for cervical adenocarcinoma at present.

Material and methods

The cervical mucus from three normal cervices (Ctrl), three endocervical adenocarcinoma (EA), and three cervical adenocarcinoma in situ (AIS) was collected for proteomic analysis. The proteins were screened using liquid chromatography-mass spectrometry analysis (LC-MS). The biological function of the differently expressed proteins were predicted by Gene Ontology (GO).

Results

A total of 711 proteins were identified, including 237 differently expressed proteins

SUBMITTER: Ma Z 

PROVIDER: S-EPMC7394065 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature