Ontology highlight
ABSTRACT:
SUBMITTER: Kodama L
PROVIDER: S-EPMC7394069 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Nature neuroscience 20191223 2
Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-spec ...[more]