Ontology highlight
ABSTRACT:
SUBMITTER: Alavi S
PROVIDER: S-EPMC7394201 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Alavi Salma S Mitchell Jonathan D JD Cho Jennifer Y JY Liu Rui R Macbeth John C JC Hsiao Ansel A
Cell 20200616 7
The gut microbiome is the resident microbial community of the gastrointestinal tract. This community is highly diverse, but how microbial diversity confers resistance or susceptibility to intestinal pathogens is poorly understood. Using transplantation of human microbiomes into several animal models of infection, we show that key microbiome species shape the chemical environment of the gut through the activity of the enzyme bile salt hydrolase. The activity of this enzyme reduced colonization by ...[more]