A palindromic RNA sequence as a common breakpoint contributor to copy-choice recombination in SARS-COV-2.

ABSTRACT: Much remains unknown concerning the origin of the novel pandemic coronavirus that has raged across the globe since emerging in Wuhan of Hubei province, near the center of the People's Republic of China, in December of 2019. All current members of the family Coronaviridae have arisen by a combination of incremental adaptive mutations, against the backdrop of many recombinational events throughout the past, rendering each a unique mosaic of RNA sequences from diverse sources. The consensus among virologists is that the base sequence of the novel coronavirus, designated SARS-CoV-2, was derived from a common ancestor of a bat coronavirus, represented by the strain RaTG13, isolated in Yunnan province in 2013. Into that ancestral genetic background, several recombination events have since occurr

SUBMITTER: Gallaher WR 

PROVIDER: S-EPMC7394270 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature