High-mobility group box-1 mediates toll-like receptor 4-dependent angiogenesis.

ABSTRACT:

Objective

Inflammation is closely linked to angiogenesis, and Toll-like receptors (TLRs) are the key mediators of inflammatory responses. However, the impact of TLRs on angiogenesis is incompletely understood. In this study, we determined the involvement of TLRs in angiogenesis.

Methods and results

In a mouse model of alkali-induced corneal neovascularization (CNV), we found that CNV was attenuated in TLR4-/- but not TLR2-/- mice. Further study revealed that the absence of TLR4 led to decreased production of proangiogenic factors in association with reduced accumulation of macrophages at the site of wounds, which was associated with reduced expression of high-mobility group box-1 (HMGB1) protein, an endogenous ligand for TLR4. Topical application of HMGB1 to the injured corn

SUBMITTER: Lin Q 

PROVIDER: S-EPMC7394281 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature