Estrone Is a Strong Predictor of Circulating Estradiol in Women Age 70 Years and Older.

ABSTRACT: After menopause, estradiol (E2) is predominately an intracrine hormone circulating in very low serum concentrations. The objective of this work is to examine determinants of E2 concentrations in women beyond age 70 years. A cross-sectional, community-based study was conducted. A total of 5325 women participated, with a mean age of 75.1 years (± 4.2 years) and not using any sex steroid, antiandrogen/estrogen, glucocorticoid, or antiglycemic therapy. Sex steroids were measured by liquid chromatography-tandem mass spectrometry. Values below the limit of detection (LOD; E2 11 pmol/L [3 pg/mL] were assigned a value of LOD/√2 to estimate total E2. E2 and estrone (E1) were below the LOD in 66.1% and 0.9% of women, respectively. The median (interdecile ranges) for E1 and detectable E2 were 181.2 p

SUBMITTER: Davis SR 

PROVIDER: S-EPMC7394338 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature