Host Genetic Factors Associated with Vaginal Microbiome Composition in Kenyan Women.

ABSTRACT: Bacterial vaginosis (BV) affects 20% of women worldwide and is associated with adverse reproductive health outcomes and increased risk for HIV. Typically, BV represents a shift in the vaginal microbiome from one that is dominated by Lactobacillus to one that is diverse. Persistent racial differences in BV and diverse vaginal microbiome composition overlap with racial disparities in risks for HIV and sexually transmitted infection, especially among women of African descent. Risk factors for BV and nonoptimal vaginal microbiome include sexual practices, yet racial differences persist when adjusted for behavioral factors, suggesting a host genetic component. Here, we perform a genome-wide association study on vaginal microbiome traits in Kenyan women. Linear regression and logistic reg

SUBMITTER: Mehta SD 

PROVIDER: S-EPMC7394359 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature