What Do Animal Models Teach Us About Congenital Craniofacial Defects?

ABSTRACT: The formation of the head and face is a complex process which involves many different signaling cues regulating the migration, differentiation, and proliferation of the neural crest. This highly complex process is very error-prone, resulting in craniofacial defects in nearly 10,000 births in the United States annually. Due to the highly conserved mechanisms of craniofacial development, animal models are widely used to understand the pathogenesis of various human diseases and assist in the diagnosis and generation of preventative therapies and treatments. Here, we provide a brief background of craniofacial development and discuss several rare diseases affecting craniofacial bone development. We focus on rare congenital diseases of the cranial bone, facial jaw bones, and two classes of disea

SUBMITTER: Ibarra BA 

PROVIDER: S-EPMC7394376 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature