AHRR cg05575921 methylation in relation to smoking and PM_2.5 exposure among Taiwanese men and women.

ABSTRACT:

Background

Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM_2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. AHRR cg05575921 and coagulation factor II (thrombin) receptor-like 3 (F2RL3) cg03636183 methylation patterns are well-established biomarkers for smoking. Even though AHRR cg05575921 methylation has recently been associated with PM_2.5, the interaction between smoking and PM_2.5 on AHRR methylation is yet to be fully explored. We evaluated AHRR and F2RL3 CpG sites to identify potential significant markers in relation to PM_2.5 and smoking in Taiwanese adults.

Methods

DNA methylation and smoking data of 948 participants aged 30-70 years wer

SUBMITTER: Tantoh DM 

PROVIDER: S-EPMC7394684 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature