Two dynamically distinct circuits drive inhibition in the sensory thalamus.

ABSTRACT: Most sensory information destined for the neocortex is relayed through the thalamus, where considerable transformation occurs^1,2. One means of transformation involves interactions between excitatory thalamocortical neurons that carry data to the cortex and inhibitory neurons of the thalamic reticular nucleus (TRN) that regulate the flow of those data^3-6. Although the importance of the TRN has long been recognised^7-9, understanding of its cell types, their organization and their functional properties has lagged behind that of the thalamocortical systems they control. Here we address this by investigating the somatosensory and visual circuits of the TRN in mice. In the somatosensory TRN we observed two groups of genetically defined neurons that are topographi

SUBMITTER: Martinez-Garcia RI 

PROVIDER: S-EPMC7394732 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature