Human Cytomegalovirus Utilizes Extracellular Vesicles To Enhance Virus Spread.

ABSTRACT: Human cytomegalovirus (HCMV) manipulates cellular processes associated with secretory pathways within an infected cell to facilitate efficient viral replication. However, little is known about how HCMV infection alters the surrounding cellular environment to promote virus spread to uninfected cells. Extracellular vesicles (EVs) are key signaling molecules that are commonly altered in numerous disease states. Previous reports have shown that viruses commonly alter EVs, which can significantly impact infection. This study finds that HCMV modulates EV biogenesis machinery through upregulation of the endosomal sorting complex required for transport (ESCRT) proteins. This regulation appears to increase the activity of EV biogenesis, since HCMV-infected fibroblasts have increased vesicle release

SUBMITTER: Streck NT 

PROVIDER: S-EPMC7394901 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature