Regulation of inflammation in diabetes: From genetics to epigenomics evidence.

ABSTRACT:

Background

Diabetes is one of the greatest public health challenges worldwide, and we still lack complementary approaches to significantly enhance the efficacy of preventive and therapeutic approaches. Genetic and environmental factors are the culprits involved in diabetes risk. Evidence from the last decade has highlighted that deregulation in the immune and inflammatory responses increase susceptibility to type 1 and type 2 diabetes. Spatiotemporal patterns of gene expression involved in immune cell polarisation depend on genomic enhancer elements in response to inflammatory and metabolic cues. Several studies have reported that most regulatory genetic variants are located in the non-protein coding regions of the genome and particularly in enhancer regions. The progress of high-t

SUBMITTER: Diedisheim M 

PROVIDER: S-EPMC7394913 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature