Solvent-Assisted Secondary Drying of Spray-Dried Polymers.

ABSTRACT:

Purpose

The purpose of this work is to introduce solvent-assisted secondary drying, a method used to accelerate the residual solvent removal from spray dried materials. Spray-drying is used to manufacture amorphous solid dispersions, which enhance the bioavailability of active pharmaceutical ingredients (APIs) with low aqueous solubility. In the spray-drying process, API and excipients are co-dissolved in a volatile organic solvent, atomized into droplets through a nozzle, and introduced to a drying chamber containing heated nitrogen gas. The product dries rapidly to form a powder, but small amounts of residual solvent (typically, 1 to 10 wt%) remain in the product and must be removed in a secondary-drying process. For some spray-dried materials, secondary drying by traditional tec

SUBMITTER: Shepard KB 

PROVIDER: S-EPMC7395053 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature