Role of FTO and MC4R Polymorphisms in Escalating Obesity and Their Indirect Association With Risk of T2D in Indian Population.

ABSTRACT:

Introduction

Obesity plays a pivotal role in the development of metabolic syndrome-excessive body fat, spikes in blood glucose levels and hypertension-and ultimately leads to cardiovascular diseases and type 2 diabetes (T2D), if left unattended. The present study aimed to investigate the associated risk of T2D with obesity risk alleles of fat mass and obesity-associated (FTO) and melanocortin 4 receptor (MC4R) genes.

Methods

The study includes 400 subjects (300 T2D diabetic cases and 100 healthy controls). Genetic analysis was done by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods.

Results

The findings of the study show no significant increase in odds of diabetes associated with the prevalence of FTO and MC4R minor alleles. R

SUBMITTER: Khan S 

PROVIDER: S-EPMC7395207 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature