Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes.

ABSTRACT: Vaccination has been used to control the spread of seasonal flu; however, the virus continues to evolve and escape from host immune response through mutation and increasing glycosylation. Efforts have been directed toward development of a universal vaccine with broadly protective activity against multiple influenza strains and subtypes. Here we report the design and evaluation of various chimeric vaccines based on the most common avian influenza H5 and human influenza H1 sequences. Of these constructs, the chimeric HA (cHA) vaccine with consensus H5 as globular head and consensus H1 as stem was shown to elicit broadly protective CD4⁺ and CD8⁺ T cell responses. Interestingly, the monoglycosylated cHA (cHA_mg) vaccine with GlcNAc on each glycosite induced more

SUBMITTER: Liao HY 

PROVIDER: S-EPMC7395492 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature