Altered gut microbiota associated with symptom severity in schizophrenia.

ABSTRACT:

Background

The gut microbiome and microbiome-gut-brain (MGB) axis have been receiving increasing attention for their role in the regulation of mental behavior and possible biological basis of psychiatric disorders. With the advance of next-generation sequencing technology, characterization of the gut microbiota in schizophrenia (SZ) patients can provide rich clues for the diagnosis and prevention of SZ.

Methods

In this study, we compared the differences in the fecal microbiota between 82 SZ patients and 80 demographically matched normal controls (NCs) by 16S rRNA sequencing and analyzed the correlations between altered gut microbiota and symptom severity.

Results

The alpha diversity showed no significant differences between the NC and SZ groups, but the beta diversity

SUBMITTER: Li S 

PROVIDER: S-EPMC7395597 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature