A miRNA biosensor based on localized surface plasmon resonance enhanced by surface-bound hybridization chain reaction.

ABSTRACT: The dysregulation of the concentration of individual circulating microRNAs or small sets of them has been recognized as a marker of disease. For example, an increase of the concentration of circulating miR-17 has been linked to lung cancer and metastatic breast cancer, while its decrease has been found in multiple sclerosis and gastric cancer. Consequently, techniques for the fast, specific and simple quantitation of microRNAs are becoming crucial enablers of early diagnosis and therapeutic follow-up. DNA based biosensors can serve this purpose, overcoming some of the drawbacks of conventional lab-based techniques. Herein, we report a cost-effective, simple and robust biosensor based on localized surface plasmon resonance and hybridization chain reaction. Immobilized gold nanoparticles are

SUBMITTER: Miti A 

PROVIDER: S-EPMC7395652 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature