Genetic variants that associate with cirrhosis have pleiotropic effects on human traits.

ABSTRACT:

Background and aims

Cirrhosis is characterized by extensive fibrosis of the liver and is a major cause of liver-related mortality. Cirrhosis is partially heritable but genetic contributions to cirrhosis have not been systemically explored. Here, we carry out association analyses with cirrhosis in two large biobanks and determine the effects of cirrhosis associated variants on multiple human disease/traits.

Methods

We carried out a genome-wide association analysis of cirrhosis as a diagnosis in UK BioBank (UKBB; 1088 cases vs. 407 873 controls) and then tested top-associating loci for replication with cirrhosis in a hospital-based cohort from the Michigan Genomics Initiative (MGI; 875 cases of cirrhosis vs. 30 346 controls). For replicating variants or variants previously ass

SUBMITTER: Chen VL 

PROVIDER: S-EPMC7395656 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature