Dataset Information
Parvovirus B19-Infected Tubulointerstitial Nephritis in Hereditary Spherocytosis.
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ABSTRACT: Background
Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis.Methods
Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure.Results
A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells.Conclusions
Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.
SUBMITTER: Nishiyama K
PROVIDER: S-EPMC7395673 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Parvovirus B19-Infected Tubulointerstitial Nephritis in Hereditary Spherocytosis.
Open forum infectious diseases 20200706 8
<h4>Background</h4>Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis.<h4>Methods</h4>Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure.<h4>Results</h4>A kidney biopsy resulted in a histop ...[more]
