Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer.

ABSTRACT: The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify the co-deregulated genes (co-DEGs), explore their molecular networks, and spot the major hub proteins within these networks. We reanalyzed 19 GEO gene expression profiles to identify and annotate CRC versus normal signatures, single-gene perturbation, and single-drug perturbation signatures. We identified the co-DEGs across different studies, their upstream regulating kinases and transcription factors (TFs). Connectivity Map was used to identify likely repurposing drugs against CRC within each group. The functional changes of the co-upregulated genes in the first category were mainly associated with negative regulation of transforming growth f

SUBMITTER: Mastrogamvraki N 

PROVIDER: S-EPMC7395738 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature