Peptides targeting dengue viral nonstructural protein 1 inhibit dengue virus production.

ABSTRACT: Viruses manipulate the life cycle in host cells via the use of viral properties and host machineries. Development of antiviral peptides against dengue virus (DENV) infection has previously been concentrated on blocking the actions of viral structural proteins and enzymes in virus entry and viral RNA processing in host cells. In this study, we proposed DENV NS1, which is a multifunctional non-structural protein indispensable for virus production, as a new target for inhibition of DENV infection by specific peptides. We performed biopanning assays using a phage-displayed peptide library and identified 11 different sequences of 12-mer peptides binding to DENV NS1. In silico analyses of peptide-protein interactions revealed 4 peptides most likely to bind to DENV NS1 at specific positions and t

SUBMITTER: Songprakhon P 

PROVIDER: S-EPMC7395749 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature