An in-silico study of cancer cell survival and spatial distribution within a 3D microenvironment.

ABSTRACT: 3D cell cultures are in-vitro models representing a significant improvement with respect to traditional monolayers. Their diffusion and applicability, however, are hampered by the complexity of 3D systems, that add new physical variables for experimental analyses. In order to account for these additional features and improve the study of 3D cultures, we here present SALSA (ScAffoLd SimulAtor), a general purpose computational tool that can simulate the behavior of a population of cells cultured in a 3D scaffold. This software allows for the complete customization of both the polymeric template structure and the cell population behavior and characteristics. In the following the technical description of SALSA will be presented, together with its validation and an example of how it could be us

SUBMITTER: Cortesi M 

PROVIDER: S-EPMC7395763 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature