Concomitant DNA methylation and transcriptome signatures define epidermal responses to acute solar UV radiation.

ABSTRACT: The simultaneous analysis of different regulatory levels of biological phenomena by means of multi-omics data integration has proven an invaluable tool in modern precision medicine, yet many processes ultimately paving the way towards disease manifestation remain elusive and have not been studied in this regard. Here we investigated the early molecular events following repetitive UV irradiation of in vivo healthy human skin in depth on transcriptomic and epigenetic level. Our results provide first hints towards an immediate acquisition of epigenetic memories related to aging and cancer and demonstrate significantly correlated epigenetic and transcriptomic responses to irradiation stress. The data allowed the precise prediction of inter-individual UV sensitivity, and molecular subtyping on

SUBMITTER: Holzscheck N 

PROVIDER: S-EPMC7395768 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature