In-silico study of the cardiac arrhythmogenic potential of biomaterial injection therapy.

ABSTRACT: Biomaterial injection is a novel therapy to treat ischemic heart failure (HF) that has shown to reduce remodeling and restore cardiac function in recent preclinical studies. While the effect of biomaterial injection in reducing mechanical wall stress has been recently demonstrated, the influence of biomaterials on the electrical behavior of treated hearts has not been elucidated. In this work, we developed computational models of swine hearts to study the electrophysiological vulnerability associated with biomaterial injection therapy. The propagation of action potentials on realistic biventricular geometries was simulated by numerically solving the monodomain electrophysiology equations on anatomically-detailed models of normal, HF untreated, and HF treated hearts. Heart geometries were c

SUBMITTER: Ramirez WA 

PROVIDER: S-EPMC7395773 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature