Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems.

ABSTRACT: Non-enzymatic proteins including antibodies function as biomarkers and are used as biopharmaceuticals in several diseases. Protein-responsive soft materials capable of the controlled release of drugs and proteins have potential for use in next-generation diagnosis and therapies. Here, we describe a supramolecular/agarose hydrogel composite that can release a protein in response to a non-enzymatic protein. A non-enzymatic protein-responsive system is developed by hybridization of an enzyme-sensitive supramolecular hydrogel with a protein-triggered enzyme activation set. In situ imaging shows that the supramolecular/agarose hydrogel composite consists of orthogonal domains of supramolecular fibers and agarose, which play distinct roles in protein entrapment and mechanical stiffness, respecti

SUBMITTER: Shigemitsu H 

PROVIDER: S-EPMC7395795 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature