Memory T cell-mediated rejection is mitigated by FcγRIIB expression on CD8⁺ T cells.

ABSTRACT: Donor-reactive memory T cells generated via heterologous immunity represent a potent barrier to long-term graft survival following transplantation because of their increased precursor frequency, rapid effector function, altered trafficking patterns, and reduced reliance on costimulation signals for activation. Thus, the identification of pathways that control memory T cell survival and secondary recall potential may provide new opportunities for therapeutic intervention. Here, we discovered that donor-specific effector/memory CD8⁺ T cell populations generated via exposure to acute vs latent vs chronic infections contain differential frequencies of CD8⁺ T cells expressing the inhibitory Fc receptor FcγRIIB. Results indicated that frequencies of FcγRIIB-expressing CD8

SUBMITTER: Morris AB 

PROVIDER: S-EPMC7395896 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature