A Feasibility Study of Drug-Drug Interaction Signal Detection in Regular Pharmacovigilance.

ABSTRACT:

Introduction

Adverse drug reactions related to drug-drug interactions cause harm to patients. There is a body of research on signal detection for drug interactions in collections of individual case reports, but limited use in regular pharmacovigilance.

Objective

The aim of this study was to evaluate the feasibility of signal detection of drug-drug interactions in collections of individual case reports of suspected adverse drug reactions.

Methods

This study was conducted in VigiBase, the WHO global database of individual case safety reports. The data lock point was 31 August 2016, which provided 13.6 million reports for analysis after deduplication. Statistical signal detection was performed using a previously developed predictive model for possible drug interactions.

SUBMITTER: Hult S 

PROVIDER: S-EPMC7395907 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature