Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes.

ABSTRACT: The laboratory rat has been used for a long time as the model of choice in several biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide range of phenotypes and providing many models of human traits and diseases. Rat genome mapping and genomics was considerably developed in the last decades. The availability of these resources has stimulated numerous studies aimed at discovering causal disease genes by positional identification. Numerous rat genes have now been identified that underlie monogenic or complex diseases and remarkably, these results have been translated to the human in a significant proportion of cases, leading to the identification of novel human disease susceptibility genes, helping in studying the mechanisms underlying the pathological abnorma

SUBMITTER: Szpirer C 

PROVIDER: S-EPMC7395987 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature