Differential expression of immune related genes in high-grade ovarian serous carcinoma.

ABSTRACT:

Objective

To identify novel immunologic targets and biomarkers associated with overall survival (OS) in high-grade serous ovarian cancer (HGSC).

Methods

In this retrospective study, microarray data from 51 HGSC specimens were analyzed (Affymetrix HG-U133A). A panel of 183 immune/inflammatory response related genes linked to 279 probe sets was constructed a priori and screened. Associations between gene expression and OS were assessed using logrank tests. Multiple testing was addressed within the False Discovery Rate (FDR) framework. For external validation, TCGA Ovarian dataset and five GSE publicly available HGSC datasets were evaluated.

Results

In Duke data, 110 probe sets linked to 83 immunologic/inflammatory-related genes were differentially expressed in tumors fr

SUBMITTER: Siamakpour-Reihani S 

PROVIDER: S-EPMC7396156 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature