Progression to colectomy in the era of biologics: A single center experience with pediatric ulcerative colitis.

ABSTRACT:

Background/purpose

Clinical outcomes in pediatric ulcerative colitis (UC) in the era of biologic agents are poorly defined. We aimed to describe risk factors for colectomy in pediatric UC in the era of infliximab therapy.

Methods

We reviewed 217 pediatric patients at Texas Children's Hospital with newly diagnosed UC between 2003 and 2015; 117 had a minimum of 5 years of follow-up. Extent of disease at diagnosis, medication exposure, the presence of extraintestinal manifestations (EIMs), and need for surgery were noted.

Results

Average length of follow up was 5.02 ± 2.27 years. Forty-two percent presented with pancolitis. Infliximab was used in 39%, immunomodulators in 65%, and steroids in 89% of patients. EIMs occurred in 24.9% of patients. The cumulative rate of cole

SUBMITTER: Ihekweazu FD 

PROVIDER: S-EPMC7396289 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature