Analysis of targeted somatic mutations in pleomorphic carcinoma of the lung using next-generation sequencing technique.

ABSTRACT:

Background

Pleomorphic carcinoma (PC) of the lung is a rare type of lung cancer with aggressive characteristics and a poor prognosis. Because it is rare, the molecular characteristics of PC remain unclear.

Methods

A gene mutation analysis was performed using next-generation sequencing (NGS) in patients with PC of the lung who had undergone surgical resection.

Results

A total of nine patients were enrolled in the study. All the patients were male and eight had a history of smoking. Eight tumors contained spindle cells and three contained giant cells. Mutations considered significant were found in eight of the nine patients: in TP53 in five patients, in MET in two patients, and in ALK, ERBB2, PIK3CA, APC, NF1, and CDKN2A in one patient each. No EGFR mutation was detecte

SUBMITTER: Manabe S 

PROVIDER: S-EPMC7396383 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature