Elevated KLF7 levels may serve as a prognostic signature and might contribute to progression of squamous carcinoma.

ABSTRACT: Global efforts have been undertaken to define the genome-wide distribution of epigenetic markers in cancerous tissues, which provide an invaluable opportunity to understand cancer biology and identify predictive signatures. Several studies have focused on the gene expression patterns of squamous carcinoma to identify tumor subtypes and find prognostic and therapeutic targets because squamous carcinoma genomes showed high instability. However, the number of reliable reports referring prognostic significance of genes and their role in squamous carcinoma is still quite limited. Krüppel-like factor 7 (KLF7) is a transcription factor that is widely expressed in numerous human tissues at low levels. Members of the KLF family have established roles in tumor cell fate, stress response, cell surviv

SUBMITTER: Yang J 

PROVIDER: S-EPMC7396437 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature