From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery.

ABSTRACT: Animal poisons and venoms are comprised of different classes of molecules displaying wide-ranging pharmacological activities. This review aims to provide an in-depth view of toxin-based compounds from terrestrial and marine organisms used as diagnostic tools, experimental molecules to validate postulated therapeutic targets, drug libraries, prototypes for the design of drugs, cosmeceuticals, and therapeutic agents. However, making these molecules applicable requires extensive preclinical trials, with some applications also demanding clinical trials, in order to validate their molecular target, mechanism of action, effective dose, potential adverse effects, as well as other fundamental parameters. Here we go through the pitfalls for a toxin-based potential therapeutic drug to become eligibl

SUBMITTER: Bordon KCF 

PROVIDER: S-EPMC7396678 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature