Genetic Alterations and Transcriptional Expression of m⁶A RNA Methylation Regulators Drive a Malignant Phenotype and Have Clinical Prognostic Impact in Hepatocellular Carcinoma.

ABSTRACT: Background: N6-methyladenosine (m⁶A) RNA methylation, associated with cancer initiation and progression, is dynamically regulated by the m⁶A RNA regulators. However, its role in liver carcinogenesis is poorly understood. Methods: Three hundred seventy-one hepatocellular carcinoma (HCC) patients from The Cancer Genome Atlas database with sequencing and copy number variations/mutations data were included. Survival analysis was performed using Cox regression model. We performed gene set enrichment analysis to explore the functions associated with different HCC groups. Finally, we used a machine-learning model on selected regulators for developing a risk signature (m⁶Ascore) The prognostic value of m⁶Ascore was finally validated in anot

SUBMITTER: Zhu GQ 

PROVIDER: S-EPMC7396691 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature