Adverse events associated with prophylactic corticosteroid use before extubation: a cohort study.

ABSTRACT:

Background

Systemic corticosteroid use is recommended before extubation in mechanically ventilated patients to prevent postextubation airway complications and reintubation. However, the adverse events associated with such use remain unclear. This study aimed to describe the incidence of adverse events associated with prophylactic corticosteroid use before extubation in mechanically ventilated adult patients.

Methods

This is a retrospective cohort study of 251 mechanically ventilated adults who received prophylactic corticosteroids in the intensive care units of four tertiary-care hospitals. The patients received 20 mg methylprednisolone at 12, 8, 4, and 0 hours before extubation (total dose, 80 mg) and were followed for 72 hours after extubation. The primary outcome was a cl

SUBMITTER: Kuriyama A 

PROVIDER: S-EPMC7396740 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature