Immune-related genes play an important role in the prognosis of patients with testicular germ cell tumor.

ABSTRACT:

Background

Testicular cancer is a very common malignancy in young men. Although testicular cancer has a high cure rate, patients have a high long-term risk of secondary malignant tumors and cardiovascular disease. In addition, for patients resistant to traditional treatment methods, new treatment methods and methods for predicting prognosis are also urgently needed.

Methods

Gene expression profiles of 165 normal testicular tissues and 156 testicular germ cell tumor (TGCT) tissues from GTEx database and TCGA database were used to obtain differentially expressed genes (DEGs) in TGCT. Through the ImmPort database, we obtained immune-related genes (IRGs). Univariate Cox regression analysis was used to identify prognostic IRGs. A transcription factor regulatory network was constr

SUBMITTER: Ji C 

PROVIDER: S-EPMC7396763 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature