Methylation of the MAOA promoter is associated with schizophrenia.

ABSTRACT:

Background

Earlier studies have shown that patients with schizophrenia have abnormalities in DNA methylation. Monoamine oxidase A (MAOA) has been extensively studied due to its biological role in neurological function. However, the relationship between the DNA methylation of the MAOA gene and schizophrenia is unclear. This study aims to elucidate the relationship between the methylation of the MAOA gene promoter and schizophrenia.

Methods

There were 151 individuals with schizophrenia (104 males and 47 females), which were diagnosed according to DSM-V, the DNA of peripheral blood of all samples was extracted and chemically modified with bisulfite. The promoter region of MAOA gene was sequenced by Methylation Target Technical Method (MethylTargetTM)

SUBMITTER: Yang H 

PROVIDER: S-EPMC7396778 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature