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In Vitro Anticancer and Radiosensitizing Activities of Phlorethols from the Brown Alga Costaria costata.

ABSTRACT: The anticancer and radiosensitizing effects of high-molecular-weight phlorethols CcPh (Mw = 2520 Da) isolated from the brown algae of Costaria costata on human colorectal carcinoma HCT 116 and HT-29 cells were investigated. Phlorethols CcPh possessed cytotoxic activity against HT-29 (IC50 = 92 μg/mL) and HCT 116 (IC50 = 94 μg/mL) cells. CcPh at non-toxic concentrations inhibited the colony formation in colon cancer cells and significantly enhanced their sensitivity to low non-toxic X-ray irradiation. The combinatory effect of radiation and CcPh was synergistic (Combination index < 0.7). Algal phlorethols might be prospective candidates as radiosensitizers to improve the scheme of radiotherapy.

SUBMITTER: Malyarenko OS

PROVIDER: S-EPMC7396992 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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In Vitro Anticancer and Radiosensitizing Activities of Phlorethols from the Brown Alga Costaria costata.

Malyarenko Olesya S OS Imbs Tatiana I TI Ermakova Svetlana P SP

Molecules (Basel, Switzerland) 20200714 14

The anticancer and radiosensitizing effects of high-molecular-weight phlorethols CcPh (Mw = 2520 Da) isolated from the brown algae of Costaria costata on human colorectal carcinoma HCT 116 and HT-29 cells were investigated. Phlorethols CcPh possessed cytotoxic activity against HT-29 (IC50 = 92 μg/mL) and HCT 116 (IC50 = 94 μg/mL) cells. CcPh at non-toxic concentrations inhibited the colony formation in colon cancer cells and significantly enhance ...[more]

PMID: 32674415

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