Genetic Variation in Complex Traits in Transgenic α-Synuclein Strains of Caenorhabditis elegans.

ABSTRACT: Different genetic backgrounds can modify the effect of mutated genes. Human α-synuclein (SNCA) gene encodes α-synuclein, and its oligomeric complexes accumulate with age and mediate the disruption of cellular homeostasis, resulting in the neuronal death that is characteristic of Parkinson's Disease. Polymorphic variants modulate this complex pathologic mechanism. Previously, we constructed five transgenic introgression lines of a Caenorhabditis elegans model of α-synuclein using genetic backgrounds that are genetically diverse from the canonical wild-type Bristol N2. A gene expression analysis revealed that the α-synuclein transgene differentially affects genome-wide transcription due to background modifiers. To further investigate how complex traits are affected in these transgenic lines,

SUBMITTER: Wang YA 

PROVIDER: S-EPMC7397059 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature